I like this lecture from Osho on social conditioning. Conditioning drives one mad, takes us away from happiness within; very easy yet very difficult device to escape from.
At the root is social conditioning and fickle state of human mind. I believe this is what we call Maya, entirely a creation of human mind, effectively preventing us from enjoyment, replacing observation with perception
Solution, by no means, is to run away into Himalayas. Happiness is not in Himalayas. Happiness is not in isolation. Happiness is not in the external world.
Happiness is not inaction. Happiness is not absence of desire. Happiness of state being at peace with yourself and the world at large irrespective of whatever transpires. After all, you have not much of control on what happens, and, that does not really matter barring perceptive influences